9. Mechanism Monday – The Endgame of Overman’s Total Synthesis of Actinophyllic Acid

Well, this is what I consider a classic. I have proposed it a couple of times in group meetings and it has never ceased to amaze me.

This, Ladies and Gentlemen, is what I call a spectacular endgame! Four reactions for the price of one!

Have a close look at it, give it a try, and get back to the original paper once you have found a satisfactory mechanism.

9Reference: J. Am. Chem. Soc. 2010 4894-4906 link


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s