Base-controlled enantiodivergence in α-aminonitrile acylation.

The groups of Prof. Takeda (Hiroshima University) and Dr. Otani (The University of Tokyo) have come across a rather surprising outcome in the α-acylation of aminonitriles: under otherwise identical conditions, the choice of base (LDA vs. MHMDS) had a dramatic influence on the retention or inversion of the stereocentre.

11Reference: Angew. Chem. Int. Ed. 2013, 12956-12960. link

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