Mechanism Monday – The Synthesis of furo-fused oxazinanes via gold asymmetric catalysis

Recently, the team of Prof. Zhang (East China Normal University, Shanghai) reported a new asymmetric heterocycle synthesis using gold catalysis (yes, you have understood by now, I am quite a big fan of gold catalysis). I propose two examples to solve, they are directly extracted from the paper. For the sake of the exercise, determining the stereochemistry of the transition states are optional.

12And this one for a little twist (R and R1 are aromatic):

12b

Reference: Angew. Chem. Int. Ed. 2014, 4350-4354. link

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