9. Mechanism Monday – The Endgame of Overman’s Total Synthesis of Actinophyllic Acid

Well, this is what I consider a classic. I have proposed it a couple of times in group meetings and it has never ceased to amaze me.

This, Ladies and Gentlemen, is what I call a spectacular endgame! Four reactions for the price of one!

Have a close look at it, give it a try, and get back to the original paper once you have found a satisfactory mechanism.

9Reference: J. Am. Chem. Soc. 2010 4894-4906 link